Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?

Kant: Friend or Foe of the Believer? Plantinga and Other American Christian Responses to Kant's Epistemology

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans.

Cafestol and kahweol-diterpenes present in unfiltered coffee-strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We determined whether the coffee diterpenes may affect lipoprotein metabolism via effects on lipid transfer proteins and lecithin:cholesterol acyltransferase in a randomized, double-blind cross-over study wi...

Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe?

Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only di...

Altered Activities of Anti-atherogenic Enzymes Lecithin:cholesterol Acyltransferase, Paraoxonase and Platelet-activating Factor Acetylhydrolase in Atherosclerosis Susceptible Mice

We examined whether the putative anti-atherogenic enzymes lecithin:cholesterol acyltransferase (LCAT), paraoxonase 1 (PON) and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible Apoe-/and Ldlr-/mice and whether plasma concentrations of bioactive oxidized phospholipids accumulate in plasma. Apoe-/mice had reduced (28%) LCAT activity and ele...

Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity that nontransgenic control rabbits. This degree of overexpression was associated with a 6.7-fold increase in the plasma HDL cholesterol concentration in LCAT transgenic rabbits. On a...